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目的:观察活血化瘀中药治疗系统性红斑狼疮(systemic lupus erythematosus,SLE)的临床疗效。方法:将86例SLE患者按随机数字表法分为2组,每组43例,对照组采用糖皮质激素和环磷酰胺治疗,治疗组在对照组的基础上联合活血化瘀中药治疗,连续治疗3个月,比较两组患者治疗前及治疗结束后中医症候积分变化,检测补体C3、C4、T淋巴细胞、B淋巴细胞、NK细胞和ds-DNA抗体的变化。结果:两组中医证候积分下降,治疗组CD3-CD19+B水平降低,差异有统计学意义(t=7.273,P=0.011;t=8.415,P=0.007;t=5.639,P=0.008);补体C3、C4水平升高,CD4+、CD4+/CD8+水平升高,差异有统计学意义(t=4.552,P=0.037;t=6.372,P=0.029;t=3.714,P=0.016;t=5.837,P=0.032);对照组和治疗组抗ds-DNA抗体转阴率分别为30.23%(13例)、44.19%(19例),差异具有统计学意义(t=6.415,P=0.023;t=5.163,P=0.038)。结论:在西药治疗基础上加用活血化瘀中药治疗系统性红斑狼疮,可改善患者免疫功能,提高临床疗效。
Abstract：Objective:To observe the clinical efficacy of blood-activating and stasis-removing Chinese medicine in treating systemic lupus erythematosus(SLE). Methods:Eighty-six cases of SLE patients were divided into two groups according to random number table method,forty-three cases in each group. The control group was treated with glucocorticoid and cyclophosphamide,the treatment group was treated on the basis of control group with blood-activating and stasis-removing Chinese medicine,and the continuous treatment for 3 months. The changes of TCM symptom score and complement C3,C4,T lymphocyte,B lymphocyte,NK cell and ds-DNA antibody before treatment and after treatment were compared between the two groups. Results:The score of two groups of TCM syndromes decreased,and the level of CD3-CD19+ B in treatment group was reduced,the difference was statistically significant(t=7.273,P=0.011;t=8.415,P=0.007;t=5.639,P=0.008). Complement C3,C4 and CD4+,CD4+/CD8+ levels increased,the difference was statistically significant(t=4.552,P=0.037;t=6.372,P=0.029;t=3.714,P=0.016;t=5.837,P=0.032). The anti ds-DNA antibody negative rates in the control group and the treatment group were 30.23%(13 cases)and 44.19%(19 cases)respectively,the difference was statistically significant(t=6.415,P=0.023;t=5.163,P=0.038). Conclusion:On the basis of Western medicine combined with blood-activating and stasis-removing Chinese medicine treatment of systemic lupus erythematosus can improve immune function and enhance clinical efficacy.
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基本信息:
DOI：10.13194/j.issn.1673-842x.2018.08.040
中图分类号:R593.241
引用信息:
[1]王义,董玉山,王志文,等.活血化瘀中药治疗系统性红斑狼疮临床疗效评价[J].辽宁中医药大学学报,2018,20(08):148-151.DOI:10.13194/j.issn.1673-842x.2018.08.040.
基金信息:
河北省中医药管理局项目(2014184;2015160)