辽宁中医药大学学报

目的:探讨清热益气法联合西药治疗冠心病心绞痛患者的疗效以及对不良事件的预防效果。方法:选取2015年2月—2016年3月在我院接受治疗的冠心病心绞痛患者100例,采用随机数表法将所有的入选患者分为观察组和对照组两组,每组各50例,对照组患者给予西药治疗,观察组患者给予清热益气法联合西药治疗,比较两组患者治疗后血液流变学变化、血脂变化、临床疗效以及不良反应发生率情况。结果:治疗后,两组患者的血浆黏度、全血黏度以及纤维蛋白都有所下降,观察组(1.02±0.12)mpa·s、(2.13±0.56)mpa·s、(2.12±0.56)g/L低于对照组(2.12±0.30)mpa·s、(3.78±0.19)mpa·s、(3.02±0.26)g/L,两组比较差异显著(P<0.05);治疗后,两组患者的TG以及TC都有所下降,观察组(0.98±0.12)、(3.12±0.78)mmol/L低于对照组(1.56±0.13)、(4.98±0.99)mmol/L,两组比较差异显著(P<0.05);两组患者的HDL-C都有所升高,观察组(1.98±0.20)mmol/L高于对照组(1.10±0.09)mmol/L,两组比较差异显著(P<0.05);观察组患者治疗后的总有效率为96.00%高于对照组78.00%,两组比较差异显著(P<0.05)。两组患者治疗后不良反应发生率比较无统计学意义(P>0.05)。结论:清热益气法联合西药治疗冠心病心绞痛患者,可有效提高临床治疗效果且不良反应发生率低。

Objective:To investigate the efficacy of Qingre Yiqi method combined with Western medicine in the treatment of angina pectoris of coronary heart disease and the preventive effect of adverse events. Methods:100 patients with angina pectoris of coronary heart disease treated in our hospital from February,2015 to March,2016 were randomly divided into two groups:observation group and control group,50 cases in each group,The patients in the control group were treated with Western medicine. The patients in the observation group were treated with Qingre Yiqi method combined with Western medicine. The changes of hemorheology,blood lipid,clinical efficacy and the incidence of adverse reactions were compared between the two groups. Results:After treatment,the plasma viscosity,whole blood viscosity and fibrin of the two groups decreased(1.02±0.12)mpa·s,(2.13±0.56)mpa·s,(2.12±0.56)g/L in the observation group(2.12±0.30)mpa·s,(3.78±0.19)mpa·s,(3.02±0.26)g/L. There was significant difference between the two groups(P<0.05). After treatment,both TG and TC in the observation group(0.98±0.12),(3.12±0.78)mmol/L was significantly lower than that in the control group(1.56±0.13),(4.98±0.99)mmol/L. There was significant difference between the two groups(P<0.05). HDL-C in the observation group(1.98±0.20)mmol/L was significantly higher than that in the control group(1.10±0.09)mmol/L,the difference between the two groups was significant(P<0.05);the total effective rate in the observation group 96.00% higher than the control group 78.00%,the difference between the two groups was significant(P<0.05). There was no significant difference between the two groups in the incidence of adverse reactions after treatment(P>0.05). Conclusion:Qingre Yiqi method combined with western medicine treatment of angina pectoris in patients with coronary heart disease can effectively improve the clinical efficacy and adverse reaction rate is low.