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帕金森病作为我国乃至全球范围内的一种主要神经退行性疾病，其发病机制复杂且缺乏有效治疗药物，尽管现代医学在一定程度上能够控制病情发展，但不良反应亦不容忽视，近年来中医药在治疗帕金森病方面卓有成效，已成为重要的治疗手段之一。其中天麻作为治疗帕金森病常用的高频核心中药之一，其祛风通络、平抑肝阳、息风止痉的多种功效，使其在帕金森病的防治中展现出确切的优势。天麻化学成分颇为复杂，其中天麻素、天麻醚苷、天麻多糖、B-甾醇以及有机酸等为主要有效成分。这些成分通过多种途径在抗氧化应激、改善线粒体功能、诱导自噬、抑制蛋白异常聚集、抑制细胞凋亡以及减轻神经炎症等方面发挥抗帕金森病的作用。文章对天麻抗帕金森病的药理机制进行了深入的综述，以明确天麻及其有效成分治疗该病的相关信号通路，旨在为帕金森病的研究及治疗提供理论依据与参考。期望通过不断地研究与探索，进一步挖掘天麻的药用价值，为帕金森病的治疗带来新的突破与希望。
Abstract：Parkinson's disease as a major neurodegenerative diseases in China and the world,its pathogenesis is complex and lack of effective treatment drugs,although modern medicine to a certain extent can control the development of the disease,but the side effects should not be ignored,in recent years,traditional Chinese medicine in the treatment of Parkinson's disease is very fruitful,and has become one of the important means of treatment. As one of the high-frequency core Chinese medicines commonly used in the treatment of Parkinson's disease,Tianma(Gastrodiae Rhizoma)has a variety of efficacies such as dispelling wind and relaxing collaterals,calming liver yang,quenching wind and stopping spasms,which makes it show its definite advantages in the prevention and treatment of Parkinson's disease. The chemical composition of Tianma(Gastrodiae Rhizoma)is quite complex,in which Tianma(Gastrodiae Rhizoma),Tianma(Gastrodiae Rhizoma)ether glycosides,Tianma(Gastrodiae Rhizoma)polysaccharides,B-sterols and organic acids are the main active ingredients. These components play an anti-Parkinson's disease role through a variety of pathways,including anti-oxidative stress,improvement of mitochondrial function,induction of autophagy,inhibition of abnormal protein aggregation,inhibition of apoptosis,and reduction of neuroinflammation. In this paper,an in-depth review of the pharmacological mechanisms of Tianma(Gastrodiae Rhizoma)against Parkinson's disease was conducted to clarify the relevant signaling pathways of Tianma(Gastrodiae Rhizoma)and its active ingredients in the treatment of this disease,aiming to provide theoretical basis and reference for the research and treatment of Parkinson's disease. It is expected that through continuous research and exploration,the medicinal value of Tianma(Gastrodiae Rhizoma)will be further explored,bringing new breakthroughs and hope for the treatment of Parkinson's disease.
[1] BURCH D,SHEERIN F. Parkinson's disease[J].Lancet(London,England),2005,365(9459):622-627.
[2] ZHANG Y,WANG Z Z,SUN H M,et al. Systematic review of traditional chinese medicine for depression in Parkinson's disease[J].The American journal of Chinese medicine,2014,42(5):1035-1051.
[3] CHEN K Y,WU M Y,YANG P S,et al. Utilization of Chinese herbal medicine and its association with the risk of fracture in patients with Parkinson's disease in Taiwan[J].Journal of ethnopharmacology,2018,226:168-175.
[4] ZHAN H D,ZHOU H Y,SUI Y P,et al. The rhizome of Gastrodia elata Blume-An ethnopharmacological review[J].Journal of ethnopharmacology,2016,189:361-385.
[5] WU J,WU B,TANG C,et al. Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents[J].Molecules(Basel,Switzerland),2017,22(7):64-71.
[6] QIU F,LIU T T,QU Z W,et al. Gastrodin inhibits the activity of acid-sensing ion channels in rat primary sensory neurons[J].European journal of pharmacology,2014,731:50-57.
[7]段小花，李秀芳，周宁娜，等.天麻提取物对血管性痴呆大鼠学习记忆及海马氧化损伤的作用[J].中成药，2011,33(7):1138-1141.
[8]徐群.脑小血管病的研究进展[J].老年医学与保健，2022,28(5):961-963.
[9]郭沛鑫，雷娜，吴海妹，等.天麻醇提取物灌胃对帕金森病大鼠认知功能障碍的改善作用及其机制[J].山东医药，2020,60(27):6-10.
[10] SENONER T,DICHTL W. Oxidative Stress in Cardiovascular Diseases:Still a Therapeutic Target?[J].Nutrients,2019,11(9):734-737.
[11] WANG X L,XING G H,HONG B,et al. Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease:involvement of ERK1/2-Nrf2 signaling pathway[J].Life Sciences,2014,114(2):77-85.
[12] GANGULY U,BANERJEE A,CHAKRABARTI S S,et al.Interaction of α-synuclein and Parkin in iron toxicity on SHSY5Y cells:implications in the pathogenesis of Parkinson's disease[J].The Biochemical Journal,2020,477(6):1109-1122.
[13] K O Y H,K I M S K,K W O N S H,e t a l. 7,8,4'-Trihydroxyisoflavone,a Metabolized Product of Daidzein,Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SHSY5Y Cells[J].Biomolecules&Therapeutics,2019,27(4):363-372.
[14] HUANG J Y,YUAN Y H,YAN J Q,et al. 20C,a bibenzyl compound isolated from Gastrodia elata,protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway[J].Acta Pharmacologica Sinica,2016,37(6):731-740.
[15] ZHANG X L,YUAN Y H,SHAO Q H,et al. DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenoneinduced oxidative insult[J].Toxicology Letters,2017,271:74-83.
[16] MOU Z,YUAN Y H,LOU Y X,et al. Bibenzyl compound 20c protects against endoplasmic reticulum stress in tunicamycintreated PC12 cells in vitro[J].Acta Pharmacologica Sinica,2016,37(12):1525-1533.
[17]杜雨生，张钊，何新，等.天麻活性成分20C对6-羟基多巴胺诱导的PC12细胞损伤及帕金森病模型小鼠的保护作用[J].中国药理学与毒理学杂志，2021,35(12):897-903.
[18]文金隆，韩春妮，陈建芬，等.天麻乙酸乙酯提取物对PC12细胞氧化损伤的保护作用[J].中国实验方剂学杂志，2013,19(23):171-175.
[19] LI Q,NIU C,ZHANG X,et al. Gastrodin and Isorhynchophylline Synergistically Inhibit MPP(+)-Induced Oxidative Stress in SH-SY5Y Cells by Targeting ERK1/2 and GSK-3β Pathways:Involvement of Nrf2 Nuclear Translocation[J]. ACS Chemical Neuroscience,2018,9(3):482-493.
[20]和璐璐，樊慧杰，李艳荣，等.线粒体功能障碍与帕金森病[J].中国实用神经疾病杂志，2023,26(10):1305-1310.
[21]罗苑，陈普，杨丽萍，等.天麻醇提物对脑缺血再灌注损伤中线粒体功能障碍的影响[J].中国中药杂志，2022,47(20):5564-5573.
[22]文晓东，罗宁，周欣梅，等. miR-145-3p通过调控CaMkkβ/AMPK/CREB通路对MPP~+诱导PD细胞模型线粒体自噬的影响[J].安徽医科大学学报，2023,58(11):1846-1853.
[23]向泉，潘际刚，陈婷婷，等.天麻素改善线粒体损伤抑制LPS诱导的PC12细胞凋亡[J].中药材，2023,46(4):975-979.
[24]李晓明，荣华，潘思文，等.天麻素联合异钩藤碱通过线粒体途径抑制MPP~+诱导PC12细胞凋亡[J].天然产物研究与开发，2021,33(7):1096-1101.
[25] H E R A S-S A N D O V A L D,PéR E Z-R O J A S J M,HERNáNDEZ-DAMIáN J,et al. The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration[J]. Cellular Signalling,2014,26(12):2694-2701.
[26] WANG X S,TIAN Z,ZHANG N,et al. Protective Effects of Gastrodin Against Autophagy-Mediated Astrocyte Death[J].Phytotherapy Research:PTR,2016,30(3):386-396.
[27]杨根梦，李娟，洪仕君，等.天麻素在甲基苯丙胺诱导SHSY5Y细胞自噬中的作用及机制研究[J].中国药理学通报，2018,34(4):577-583.
[28]彭伟，张立娟，张倩，等.天麻钩藤饮对帕金森病模型大鼠纹状体α-突触核蛋白含量及自噬相关蛋白Beclin1、LC3B表达的影响[J].中医杂志，2018,59(14):1228-1231.
[29]李云攀，刘美云.天麻钩藤饮对自发性高血压大鼠血管内皮细胞自噬相关信号通路Ca~(2+)/AMPK/mTOR的影响[J].中国现代医学杂志，2018,28(22):38-43.
[30] FADOK V A,BRATTON D L,ROSE D M,et al. A receptor for phosphatidylserine-specific clearance of apoptotic cells[J].Nature,2000,405(6782):85-90.
[31] MOUJALLED D,STRASSER A,LIDDELL J R. Molecular mechanisms of cell death in neurological diseases[J]. Cell Death and Differentiation,2021,28(7):2029-2044.
[32]高小恒，陈达艳，刘效栓，等.天麻钩藤饮含药血清对脑出血大鼠血清炎症因子和血肿周围脑组织细胞凋亡相关因子表达的影响[J].中华中医药学刊，2022,40(3):232-235,59.
[33]王晓丽，崔红霞，李宏铃，等.天麻钩藤饮含药血清对MPP~+诱导PC12细胞损伤保护作用的研究[J].中药药理与临床，2017,33(6):10-13.
[34]席晅，任小琼.天麻素注射液对帕金森病大鼠的保护作用[J].中国老年学杂志，2016,36(20):4996-4997.
[35] KIM I S,CHOI D K,JUNG H J. Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxininduced dopaminergic MN9D cells[J]. Molecules(Basel,Switzerland),2011,16(7):5349-5361.
[36] DHANALAKSHMI C,JANAKIRAMAN U,MANIVASAGAM T,et al. Vanillin Attenuated Behavioural Impairments,Neurochemical Deficts,Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson's Disease[J].Neurochemical Research,2016,41(8):1899-1910.
[37]李旭，徐天娇，刘立琨，等.天麻素联合异钩藤碱抑制MPP~+诱导的PC12细胞凋亡的抗氧化机制[J].中国中药杂志，2021,46(2):420-425.
[38]冉芮，陈婷婷，陈永鑫，等.天麻素调控PINK1/Parkin-VDAC1信号改善CoCl2诱导的HT22细胞凋亡[J].中华中医药杂志，2023,38(7):3109-3114.
[39] MOEHLE M S,WEST A B. M1 and M2 immune activation in Parkinson's Disease:Foe and ally?[J]. Neuroscience,2015,302:59-73.
[40]李阳，邵宇.天麻素经TLR4-NF-κB信号通路对帕金森大鼠的干预作用[J].河北医药，2022,44(17):2591-2594.
[41]刘英杰，姜茜，张胜娜.天麻素对毛果芸香碱诱发的癫痫大鼠TLR4/NF-κB信号通路影响的研究[J].新中医，2020,52(4):1-6.
[42] JOHNSON G L,LAPADAT R. Mitogen-activated protein kinase pathways mediated by ERK,JNK,and p38 protein kinases[J].Science(New York,NY),2002,298(5600):1911-1912.
[43] SHAO Q H,ZHANG X L,CHEN Y,et al. Antineuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways[J].Molecular Immunology,2018,99:115-123.
[44] ZHANG Q S,HENG Y,CHEN Y,et al. A Novel Bibenzyl Compound(20C)Protects Mice from 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine/Probenecid Toxicity by Regulating theα-Synuclein-Related Inflammatory Response[J]. The Journal of Pharmacology and Experimental Therapeutics,2017,363(2):284-292.
[45]吴小盈，周雪，胡晓霞，等.天麻素通过调控NF-кB/NLRP3信号通路对BV2细胞炎症损伤的保护作用[J].中成药，2023,45(3):918-923.
基本信息:
DOI：10.13194/j.issn.1673-842x.2024.10.026
中图分类号:R285
引用信息:
[1]余婷,张慧,马岱朝,等.天麻及其有效成分治疗帕金森病的药理机制研究进展[J].辽宁中医药大学学报,2024,26(10):127-131.DOI:10.13194/j.issn.1673-842x.2024.10.026.
基金信息:
国家中医药管理局中医药科学技术研究专项课题（GYZ-KJS-2021-001）; 陕西省科技厅重点研发计划项目（S2021-YF-ZDCXLZDLSF-0011,2020ZDLSF05-14）; 陕西省中医药管理局中西医结合临床协作创新项目（2020-ZXY-002）; 陕西中医药大学附属医院中医临床基地建设项目（2020LCJD003）
2024-01-22
2024
2024-04-25
2024
1
2024-04-29
2024-04-29
2024-04-29