| 1,521 | 5 | 48 |
| 下载次数 | 被引频次 | 阅读次数 |
肠道菌群是人体极为重要的微生态系统,与许多疾病的发生、发展密切相关。针灸作为传统医学重要疗法之一,以其疗效显著且绿色、无毒副作用,被广泛运用于各种疾病的治疗。近年来,不断有基础研究和临床试验证实针灸通过调控机体肠道菌群状况,恢复肠道菌群的平衡状态,以达到治疗相关疾病的目的。该文总结了近年来针灸调控肠道菌群以治疗神经系统、消化系统、免疫系统、内分泌系统等相关疾病,综述其可能机制并进一步展望其发展方向。
Abstract：Intestinal flora is a very important microecosystem of human body,which is closely related to the occurrence and development of many diseases. Acupuncture and moxibustion,as one of the important traditional medicine therapies,is widely used in the treatment of various diseases because of its remarkable curative effect,green and non-toxic side effects. In recent years,there have been continuous basic studies and clinical trials to prove that acupuncture can regulate the intestinal flora of the body and restore the balance of intestinal flora to achieve the purpose of treating related diseases. This paper summarized the recent years of acupuncture and moxibustion based on the intervention of intestinal flora to treat nervous system,digestive system,immune system,endocrine system and other related diseases,reviewed its possible mechanism and further looked forward to its development direction.
[1] BARKO PC,MCMICHAEL MA,SWANSON KS. The gastrointestinal microbiome:A review[J]. J Vet Intern Med,2018,32:9-25.
[2] THAISS CA,ZMORA N,LEVY M. The microbiome and innate immunity[J]. Nature,2016,535:65-74.
[3] LYNCH SV. The human intestinal microbiome in health and disease[J]. N Engl J Med,2016,375:2369-2379.
[4] QUIGLEY MEE. Microbiota-brain-gut axis and neurodegenerative diseases[J]. Curr Neurol Neurosci Rep,2017,17:94.
[5] DIAZ HEIJTZ R,WANG S,ANUAR F,et al. Normal gut microbiota modulates brain development and behavior[J]. Proc Natl Acad Sci USA,2011,108:3047-3052.
[6] OGBONNAYA ES,CLARKE G,SHANAHAN F,et al. Adult hippocampal neurogenesis is regulated by the microbiome[J].Biol Psychiatry,2015,78:7-9.
[7] LUCZYNSKI P,WHELAN SO,O'SULLIVAN C,et al. Adult microbiota-deficient mice have distinct dendritic morphological changes:differential effects in the amyg-dala and hippocampus[J]. Eur J Neurol,2016,44:2654-2666.
[8] BRANISTE V,AL-ASMAKH M,KOWAL C,et al. The gut microbiota influences blood-brain barrier permeability in mice[J].Sci Transl Med,2014,6:263ra158.
[9] GACIAS M,GASPARI S,SANTOS PM,et al. Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior[J]. Elife,2016,5:47-54.
[10] M?HLE L,MATTEI D,HEIMESAAT MM,et al. Ly6C(hi)monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis[J]. Cell Rep,2016,15:1945-1956.
[11] ERNY D,HRABěDE ANGELIS AL,JAITIN D,et al. Host microbiota constantly control maturation and function of microglia in the CNS[J]. Nat Neurosci,2015,18:965-977.
[12] SHARON G,SAMPSON TR,GESCHWIND DH. The central nervous system and the gut microbiome[J]. Cell,2016,167:915-932.
[13] SANG HR,POTHOULAKIS C,MAYER EA. Principles and clinical implications of the brain-gut-enteric microbiota axis[J].Nature Reviews Gastroenterology&Hepatology,2009,6(5):306-314.
[14]杨玥，张丹华，陈媛，等.脑肠互动与针刺治疗功能性胃肠病的相关性[J].世界华人消化杂志，2012,20(6):491-496.
[15]常小荣，严洁，刘玉群，等.电针足三里和阳陵泉穴对家兔胃胆运动及脑肠肽的影响[J].世界华人消化杂志，2006,14(17):1662-1668.
[16] HOLMQVIST S,CHUTNA O,BOUSSET L,et al. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats[J].Acta Neuropathol,2014,128(6):805-820.
[17]于源.不同电针对帕金森模型大鼠肠道菌群AWCD值影响的实验研究[D].哈尔滨：黑龙江省中医药科学院，2018.
[18] SWIDSINSKI A,LOENING-BAUCKE V,KRüGER M,et al.Central nervous system and the colonic bioreactor:Analysis of colonic microbiota in patients with stroke unravels unknown mechanisms of the host defense after brain injury[J]. Intest Res,2012,10(4):332.
[19]刘月秋，刘辉.针灸对脑卒中患者细胞免疫功能的影响[J].光明中医，2016,31(13):1854-1855.
[20] LAN L,TAO J,CHEN A,et al. Electroacupuncture exerts antiinflammatory effects in cerebral ischemia-reperfusion injured rats via suppression of the TLR4/NF-КB pathway[J]. Int J Mol Med,2013,31(1):75-80.
[21]马继红，彭拥军，孙建华，等.肠道菌群在针灸治疗缺血性脑卒中的作用研究[J].针灸临床杂志，2019,35(3):5-9.
[22]魏大能.针灸对UC模型小鼠焦虑情绪的改善作用及其与肠道菌群的关系研究[D].成都：成都中医药大学，2017.
[23] ABDALLA MI,SANDLER RS,KAPPELMAN MD,et al.Prevalence and impact of inflammatory bowel disease-irritable bowel syndrome on patient-reported outcomes in CCFA partners[J]. Inflamm Bowel Dis,2017,23(2):325-331.
[24] HOLTMANN GJ,FORD AC,TALLEY NJ. Pathophysiology of irritable bowel syndrome[J]. Lancet Gastroenterol Hepatol,2016,1:133-146.
[25] CANAKIS ANDREW,HAROON MUSTAFA,WEBER H CHRISTIAN. Irritable bowel syndrome and gut microbiota[J].Current Opinion in Endocrinology,Diabetes,and Obesity,2020,27(1):57-68.
[26]王茜，陈侃俊，余安胜.针灸治疗肝郁脾虚型肠易激综合征疗效及机制探讨[J].中国中西医结合消化杂志，2019,27(7):520-524.
[27]刘霞.基于16S rDNA和~1H NMR技术探讨隔药饼灸对肠易激综合征大鼠肠道菌群和代谢物的影响[D].长沙：湖南中医药大学，2019.
[28]许珊珊，戴新娟.炎症性肠病患者延续护理的研究进展[J].中华护理杂志，2017,52(7):879-882.
[29]何启卓，郭彩霞.溃疡性结肠炎与克罗恩病患者肠道优势菌群的特征及与发病关系的研究[J].中国中西医结合消化杂志，2019,27(11):844-849.
[30]谢文松，魏录翠，王金周，张芳.针刺联合中药治疗溃疡性结肠炎疗效及对相关指标的影响[J].上海针灸杂志，2019,38(4):378-383.
[31]张博，熊壮，姜鑫.自拟扶正平溃汤联合针灸治疗慢性溃疡性结肠炎的疗效及对肠道菌群失调和Th17/Treg细胞免疫平衡的影响[J].现代中西医结合杂志，2018,27(11):1164-1167,1171.
[32]侯天舒，韩晓霞，杨阳，等.电针对溃疡性结肠炎大鼠肠道微生态的保护作用[J].针刺研究，2014,39(1):27-34.
[33]王园园.针灸干预对克罗恩病模型大鼠肠道菌群多样性的影响[D].长沙：湖南中医药大学，2019.
[34]林璋，祖先鹏，谢海胜，等.肠道菌群与人体疾病发病机制的研究进展[J].药学学报，2016,51(6):843-852.
[35] EGGER G. Beyond obesity and lifestyle:a review of 21st century chronic disease determinants[J].Biomed Res Int,2014,2014:731685.
[36] LEVY M,KOLODZIEJCZYK AA,THAISS CA. Dysbiosis and the immune system[J]. Nat Rev Immunol,2017,17:219-232.
[37]王海瑜，钱唐亮，康天伦，等.肠道菌群与类风湿关节炎寒热证型的相关性研究[J].中国中医药信息杂志，2020,27(6):7-12
[38]陈斌，白羽，陈芮，等.艾灸对诱导性大鼠关节炎症及肠道菌群的影响[J].中国微生态学杂志，2019,31(6):632-637.
[39]宋敏灵，秦可菁，邹勇，等.基于肠道菌群理论探讨针灸在治疗2型糖尿病中的应用[J].世界最新医学信息文摘，2019,19(82):78-79.
[40]覃佩兰，成泽东.基于脑肠轴学说探讨针灸对肠道菌群调节的思考[J].时珍国医国药，2015,26(11):2712-2714.
[41] ZHAO L. Genomics:the tale of our other genome[J].Nature,2010,465(7300):879-880.
[42]江杨洋，王旭东.生态病因学：肠道菌群失调与2型糖尿病[J].医学综述，2014,20(20):3757-3759.
[43]陈新华.“调脏通络”电针对糖尿病小鼠肠道菌群影响的研究[D].长春：长春中医药大学，2019.
[44] RE LEY. Obesity alters gut microbial ecology[J].PNAS,2005,102(31):11070-11075.
[45] PJ TURNBAUGH. An obesity-associated gut microbiome with in-creased capacity for energy harvest[J]. Nature,2006,444:1027-1031.
[46]周莉萍，胡玲香，邓雪梅，等.针灸减肥进程中患者肠道菌群的变化规律探讨[J].四川中医，2011,29(9):124-126.
[47]邓雪梅.针刺治疗单纯性肥胖的临床及实验研究[D].成都：成都中医药大学，2010.
[48]徐洁颖，陈子江，杜艳芝.肠道菌群与多囊卵巢综合征发病关系的研究进展[J].上海交通大学学报（医学版），2016,36(8):1250-1255.
[49]李菲，张宁，周冠伦.肠道菌群与多囊卵巢综合征的免疫学机制研究进展[J].现代妇产科进展，2018,27(4):308-310.
[50]彭艳，张营营，王顺，等.基于肠道菌群探讨针刺治疗多囊卵巢综合征[J].针灸临床杂志，2019,35(3):1-5.
[51] AGMON-LEVIN N,ZAFRIR Y,KIVITY S,et al. Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine:another angle of the'autoimmune(autoinflammatory)syndrome induced by adjuvants'(ASIA)[J].Immunol Res,2014(60):376-383.
[52] NAGY SZAKAL D,WILLIAMS BL,MISHRA N,et al. Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome[J]. Microbiome,2017,5(1):44-61.
[53]成泽东，陈以国，张涛.温和灸神阙穴对慢性疲劳大鼠肠道菌群的影响[J].上海针灸杂志，2013,32(1):56-58.
[54]成泽东，陈以国，张涛.温和灸对慢性疲劳大鼠肠道菌群的影响[J].中国中医药信息杂志，2013,20(1):45-46,63.
基本信息:
DOI：10.13194/j.issn.1673-842x.2020.11.002
中图分类号:R245
引用信息:
[1]彭拥军,徐疏影,李文倩,等.针灸与肠道菌群[J].辽宁中医药大学学报,2020,22(11):4-7.DOI:10.13194/j.issn.1673-842x.2020.11.002.
基金信息:
国家自然科学基金（81973932,81574060,81001556）;; 中国博士后科学基金（2015M571790）;; 江苏高校优势学科建设工程资助项目;; 南京中医药大学中医学优势学科三期项目开放课题（ZYX03KF035）;; 江苏省中医院院级课题（Y19024）;; 第六批全国老中医药专家学术经验继承人项目（国中医药人教发[2017]29号）
2020-02-17
2020
2020-03-31
2020
1
2020-11-05
2020-11-05