辽宁中医药大学学报

目的:探讨丹参多酚酸盐注射液与丹参注射液治疗冠心病的效果。方法:选取稳定型心绞痛患者140例,根据随机数字表法分为观察组和对照组,各70例。观察组静脉滴注丹参多酚酸盐进行治疗,对照组应用丹参进行治疗,观察两组治疗效果。结果:1两组患者治疗后心绞痛发作次数和硝酸甘油用量明显低于治疗前,总运动代谢当量、心绞痛诱发时间和ST段压低1 mm时间差异明显高于对照组,差异具有统计学意义(P<0.05);两组对比,观察组心绞痛发作次数和硝酸甘油用量明显低于对照组,差异有统计学意义(P<0.05)。两组间总运动代谢当量、心绞痛诱发时间和ST段压低1 mm时间差异无统计学意义(P>0.05)。2观察组总不良反应发生率为2.9%,明显低于对照组12.9%(P<0.05)。结论:丹参多酚酸盐注射液治疗冠心病效果更好、更安全,值得在临床上推广应用。

Objective:To investigate the effect of Salvianolate Injection and Salvia miltiorrhiza Injection on the treatment of coronary heart disease. Methods:140 patients with stable angina pectoris were selected,Randomly divided into observation group and control group,each of 70 cases. The observation group were treated with Salvianolate Injection,control group were treated with Salvia miltiorrhiza,observe the therapeutic effect of the two groups. Results:Two groups of patients after the treatment of angina attack frequency and nitroglycerin dosage was significantly lower than before treatment,total exercise metabolic equivalent,the time difference of ST and 1 mm in the patients with angina pectoris was significantly higher than that in the control group,the difference was statistically significant(P<0.05);Two groups of comparison,the observation group angina attack frequency and dosage of nitroglycerin were significantly lower than the control group,the difference was statistically significant(P<0.05). There was no significant difference between the two groups in the total exercise metabolic equivalent,the duration of angina pectoris and the ST segment depression(P>0.05);The incidence of adverse reactions in observation group was 2.9%,significantly higher than that in the control group(12.9%,P<0.05). Conclusion:The effect of the treatment of coronary heart disease with Salvianolate Injection is better,more secure,it is worth popularizing in clinic.