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慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）是全球三大死亡原因之一，具有极高的致残率和致死率。但该病发病机制尚未完全阐明，对其预防和治疗缺乏有效的策略和手段。近年来，脂质代谢紊乱在COPD病程进展中起到的作用被逐渐揭示。“痰邪”作为COPD的核心致病因素之一，亦与现代医学中的脂质代谢异常存在密切的联系。故从中医理论和现代医学的双重视角出发，探讨“痰”和脂质代谢异常在COPD发病过程中的内在相关性以及临床化痰方药的应用所取得的疗效，以期为中医药临床防治COPD提供新的理论依据。
Abstract：Chronic obstructive pulmonary disease(COPD)is one of the three leading causes of death in the world,with high morbidity and mortality. However,the pathogenesis of this disease has not been fully elucidated,and there is a lack of effective strategies and means for the prevention and treatment of this disease. In recent years,the role of lipid metabolism disorders in the progression of COPD has been gradually revealed. As one of the core pathogenic factors of COPD,“phlegm” is also closely related to the abnormal lipid metabolism in modern medicine. Therefore,from the dual perspective of traditional Chinese medicine theory and modern medicine,this paper discusses the internal correlation between “phlegm” and abnormal lipid metabolism in the pathogenesis of chronic obstructive pulmonary disease and the efficacy of clinical application of phlegm-resolving prescriptions,in order to provide a new theoretical basis for the clinical prevention and treatment of COPD with traditional Chinese medicine.
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基本信息:
DOI：10.13194/j.issn.1673-842X.2026.06.019
中图分类号:R259
引用信息:
[1]高萌蔓,臧凝子,吕晓东,等.基于脂质代谢探讨慢性阻塞性肺疾病“痰”生物学基础[J].辽宁中医药大学学报,2026,28(06):128-134.DOI:10.13194/j.issn.1673-842X.2026.06.019.
基金信息:
国家自然科学基金项目(82474608); 辽宁省科技计划联合计划(应用基础研究项目)项目(2023021095-JH2/1017); 辽宁省教育厅高校基本科研项目储备项目(2024-JYTCB-082)
2025-07-05
2025
2025-11-17
2025-11-19
2025
1
2025-11-20
2025-11-20
2025-11-20