辽宁中医药大学学报

目的 :系统评价安宫牛黄丸治疗出血性中风急性期的临床疗效及安全性。方法 :运用系统评价方法,检索安宫牛黄丸治疗中风的随机对照试验,筛选合格研究,评价研究质量,采用异质性检验、Meta-分析、敏感性分析、倒漏斗图等方法统计相关数据。结果 :7项研究符合选择标准,安宫牛黄丸治疗出血性中风急性期总有效率的RR(99%CI)Meta-分析结果为1.53(1.20,1.96),NNT(99%CI)为4.17(2.78,9.09)。结论 :现有证据支持说明安宫牛黄丸有益于改善出血性中风急性期患者的神经功能缺损状况。

Objective:To evaluate efficacy and safety of Angong Niuhuang pill for acute hemorrhagic stroke.Methods:Randomized controlled trails(RCTs)of Angong Niuhuang pill for acute hemorrhagic stroke were identified,eligible studies were included,the methodological quality of inclusive trails was assessed by Jadad scale.Heterogeneity test,Meta-analysis,funnel plot analysis and sensitivity analysis were used to analyze data.Results:7 RCTs were included,with all trails of low methodological quality.Meta-analysis indicated that relative risk of overall effective rate was 1.53[99%CI(1.20,1.96)],NNT(99%CI)was 4.17(2.78,9.09).Conclusion:This systematic review showed that Angong Niuhuang pill is effective for acute hemorrhagic stroke.