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槲皮素作为一种广泛存在于自然界的天然黄酮类化合物,获得深入的研究,目前已经发现它具有多重生物活性,如抗氧化、抗病毒、抗炎作用,在细胞和动物实验中可以用来治疗肝、心、脾、肺、肾、骨科疾病、神经系统疾病等。目前,关于槲皮素的研究多而杂,因此,该文从槲皮素的药理作用入手,归纳整理近年国内外发表的相关文章,以期为将来的研究提供帮助。
Abstract:Quercetin,as a kind of natural flavonoid which is widely found in nature,has been studied deeply. It has been found to have multiple biological activities,such as antioxidant,antiviral and antineoplastic activity. In cell and animal experiments,it can be used to treat liver,heart,spleen,lung,kidney,orthopedic disease,nervous system disease,etc. At present,there are many researches on quercetin. Therefore,this paper summarizes the relevant articles on the pharmacological action of quercetin in recent years and provides some help for future research.
[1]王中旺,许梦川,杨雯茜,等.槲皮素对2型糖尿病患者机体铁代谢的影响[J].河北师范大学学报(自然科学版),2017,41(3):272-276.
[2]Tang Y,Li Y,Yu H,et al.Quercetin attenuates chronic ethanol hepatotoxicity:implication of"free"iron uptake and release[J].Food&Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association,2014,67(3):131-8.
[3]杨晓敏,张天娇,许可嘉,等.葛根素、大豆素、槲皮素及芦丁对CCl4诱导小鼠急性肝损伤保护作用的比较研究[J].世界科学技术-中医药现代化-中医研究,2015,17(10):2024-2028.
[4]Lee S,Lee HH,Shin YS,et al.The anti-HSV-1 effect of quercetin is dependent on the suppression of TLR-3 in Raw 264.7cells[J].Arch Pharm Res,2017,40(5):623-630.
[5]Lee M,Son M,Ryu E,et al.Quercetin-induced apoptosis prevents EBV infection[J].Oncotarget,2015,6(14):12603-12624.
[6]Wu W,Li R,Li X,et al.Quercetin as an Antiviral Agent Inhibits Influenza A Virus(IAV)Entry[J].Viruses,2016,8(1):6.
[7]张欣,董春力,付丽丽,等.槲皮素对宫颈癌细胞Si Ha增殖的影响[J].国际妇产科学杂志,2017,44(3):304-306.
[8]魏玮,刘婷,丁波,等.槲皮素对宫颈癌裸鼠模型肿瘤生长及其对乙酰肝素酶表达的关系研究[J].中国生化药物杂志,2015,11(35):26-29.
[9]邓守恒,佐志刚,陈萍,等.槲皮素对宫颈癌放射增敏作用及机制研究[J].时珍国医国药,2016,27(9):2058-2060.
[10]Khorsandi L,Orazizadeh M,Niazvand F,et al.Quercetin induces apoptosis and necroptosis in MCF-7 breast cancer cells[J].Bratisl Lek Listy,2017,118(2):123-128.
[11]Nguyen LT,Lee YH,Sharma AR,et al.Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity[J].Korean J Physiol Pharmacol,2017,21(2):205-213.
[12]Yu D,Ye T,Xiang Y,et al.Quercetin inhibits epithelialmesenchymal transition,decreases invasiveness and metastasis,and reverses IL-6 induced epithelial-mesenchymal transition,expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells[J].Onco Targets Ther,2017(10):4719-4729.
[13]Liu Y,Tang ZG,Yang JQ,et al.Low concentration of quercetin antagonizes the invasion and angiogenesis of human glioblastoma U251 cells[J].Onco Targets Ther,2017(10):4023-4028.
[14]陶晓薇,毛其芬.槲皮素对人胶质母细胞瘤T98G凋亡及HSP27蛋白表达的干预作用[J].浙江中西医结合杂志,2015,25(5):436-438.
[15]牛国敏,张复华,杨国雷,等.Cox-2在槲皮素抑制耐药白血病HL-60、HL-60A细胞增殖中的作用[J].右江民族医学院学报,2015,37(1):14-16.
[16]黄琰,吴隼,张媛,等.槲皮素对白血病细胞杀伤作用的研究[J].中药药理与临床,2015,31(5):61-64.
[17]卢春凤,杨玉,商宇,等.ROS介导的氧化应激在INH诱导的细胞毒性中的作用及槲皮素的干预[J].生态毒理学报,2015,10(3):209-215.
[18]Wu L,Zhang Q,Mo W,et al.Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways[J].Sci Rep,2017,7(1):9289.
[19]李冬梅,张元媛,徐丽,等.槲皮素对心肌缺血再灌注损伤的保护作用及机制研究[J].实用药物与临床,2016,19(4):410-413.
[20]Chekalina NI,Shut SV,Trybrat TA,et al.Effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease[J].Wiad Lek,2017,70(4):707-711.
[21]Lin W,Wang W,Wang D,et al.Quercetin protects against atherosclerosis by inhibiting dendritic cell activation[J].Mol Nutr Food Res,2017,61(9):1700031.
[22]刘萍,唐富山,朱艳,等.槲皮素对PM2.5导致支气管上皮细胞炎症的保护作用[J].中药药理与临床,2017,33(1):22-25.
[23]史丽颖,丁辉,卢轩,等.槲皮素抗大鼠速发型过敏反应[J].中成药,2016,38(9):1906-1909.
[24]Caglayan S S,Karaman M,Cilaker M S,et al.Effects of Quercetin Treatment on Epithelium-derived Cytokines and Epithelial Cell Apoptosis in Allergic Airway Inflammation Mice Model[J].Iran J Allergy Asthma Immunol,2016,15(6):487-497.
[25]Veith C,Drent M,Bast A,et al.The disturbed redox-balance in pulmonary fibrosis is modulated by the plant flavonoidquercetin[J].Toxicol Appl Pharmacol,2017(336):40-48.
[26]吴素珍,李加林,陈水亲.槲皮素对高糖诱导肾小球系膜细胞增殖及TGF-β1/Smads信号通路的影响[J].中国中医基础医学杂志,2016,22(2):195-197.
[27]王兴红,常陆林,王桂叶,等.槲皮素对2型糖尿病大鼠肾脏肥大的影响机制[J].中国中医基础医学杂志,2015,21(10):1248-1250.
[28]Andreucci M,Faga T,Pisani A,et al.Quercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells[J].Journal of Cellular Physiology,2017,16(10):262.
[29]郭磊,孙天胜,江武,等.槲皮素对大鼠脊髓损伤的保护作用及机制探讨[J].解放军医学院学报,2016,37(2):159-163.
[30]党圆圆,张洪钿,杨艺,等.槲皮素促进小鼠脊髓损伤后轴突生长及功能恢复研究[J].解放军预防医学杂志,2016,34(4):471-474.
[31]Wang Y,Li W,Wang M,et al.Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats[J].J Cell Biochem,2017(2):1-16.
[32]Chen MM,Qin J,Chen SJ,et al.Quercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL/6J mice[J].J Nutr Biochem,2017(46):57-67.
[33]黄敬群,刘久红,李伟中,等.槲皮素对急性痛风性关节炎大鼠的治疗作用及其对肝功能的影响[J].山东医药,2015,55(28):27-29.
[34]Ruiz-Miyazawa KW,Staurengo-Ferrari L,Mizokami SS,et al.Quercetin inhibits gout arthritis in mice:induction of an opioid-dependent regulation of inflammasome[J].Inflammopharmacology,2017(1):1-16.
[35]袁小亮,李林福,施伟梅,等.槲皮素对关节软骨中MMP-13、TIMP-1表达的影响[J].时珍国医国药,2016,27(2):283-285.
[36]卞伟,孙宏,刘凯,等.槲皮素对骨质疏松大鼠骨生物力学性能及骨代谢的影响[J].吉林中医药,2016,36(8):814-817.
[37]Bao D,Wang J,Pang X,et al.Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma(PC-12)Cells[J].Molecules,2017,22(7):1122.
[38]易波,戴宜武.槲皮素对脑卒中神经损伤修复的研究进展[J].中华神经创伤外科电子杂志,2016,2(3):181-183.
[39]Chen BH,Park JH,Ahn JH,et al.Pretreated quercetin protects gerbil hippocampal CA1 pyramidal neurons from transient cerebral ischemic injury by increasing the expression of antioxidant enzymes[J].Neural Regen Res,2017,12(2):220-227.
[40]Singh S,Kumar P.Piperine in combination with quercetin halt6-OHDA induced neurodegeneration in experimental rats:Biochemical and neurochemical evidences[J].Neurosci Res,2017(17):30352-30358.
[41]Singh S,Jamwal S,Kumar P.Neuroprotective potential of Quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity[J].Neural Regen Res,2017,12(7):1137-1144.
[42]Dong F,Wang S,Wang Y,et al.Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice[J].Biochem Biophys Res Commun,2017,491(3):636-641.
[43]Gao F J,Zhang S H,Xu P,et al.Quercetin Declines Apoptosis,Ameliorates Mitochondrial Function and Improves Retinal Ganglion Cell Survival and Function in In Vivo Model of Glaucoma in Rat and Retinal Ganglion Cell Culture In Vitro[J].Frontiers in Molecular Neuroscience,2017(10):285.
[44]Ola MS,Ahmed MM,Shams S1,et al.Neuroprotective effects of quercetin in diabetic rat retina[J].Saudi J Biol Sci,2017,24(6):1186-1194.
[45]Weng S,Mao L,Gong Y1,et al.Role of quercetin in protecting ARPE 19 cells against H2O2 induced injury via nuclear factor erythroid 2 like 2 pathway activation and endoplasmic reticulum stress inhibition[J].Mol Med Rep,2017,16(3):3461-3468.
基本信息:
DOI:10.13194/j.issn.1673-842x.2018.08.061
中图分类号:R285
引用信息:
[1]马纳,李亚静,范吉平.槲皮素药理作用研究进展[J].辽宁中医药大学学报,2018,20(08):221-224.DOI:10.13194/j.issn.1673-842x.2018.08.061.
2018-07-11
2018-07-11
2018-07-11